Immunoinformatics in COVID-19 Vaccine Development: The Role of HLA System

Individual genetic variation may help to explain different immune responses a coronavirus SARS-CoV-2 across population. The in silico computer simulation methodology provides the experimental community with more complete list of immunogenic peptides presented by antigens HLA system. This review considers an array computationally predicted from for vitro functional validation and potential vaccine devel-opments. Several independent studies conducted approaches showed high degree confidence reproducibility results. Computer-assisted prediction is instrumental quick cost-effective solution prevent spread ultimately eliminate infection. Most efforts develop vaccines drugs against target spike glycoprotein (protein S), major inducer neutralizing antibodies. candidates have been shown be effective progressed randomized trials an-imals or humans COVID-19 ar-ticle highlights current advances development subunit combat that are reducing time costs development. © 2021, Universitatsklinikum Hamburg - Eppendorf. All rights reserved.